Jermell Charlo faces Brian Castano in the 12-round main event in one of the most anticipated boxing rematches. The main card of Dignity Health Sports Park's boxing program in Carson, Calif. features their showdown. It starts at 9 p.m. ET on Showtime The combatants had an intense battle that ended in a draw last July. Both have pledged to keep the judges out of their rematch. Charlo (34-1-1; 18 KOs), puts his WBC and WBA belts on the line, while Castano (170-2, 12KOs), brings his WBO title.

Caesars Sportsbook's latest odds for Charlo and Castano show Charlo as the favorite at -220 (risk $220 to Win $100), while Castano is the underdog at +180. The total rounds are over-under at 10.5, while the over-under is -270. Other Charlo Castano props are available, including whether the fight will go to the finish (yes -220 and no +170). Before you make any Charlo-vs. Castano 2 picks be sure to check out Brandon Wise's boxing predictions.

Wise is the CBS Sports combat sports editor. He is an expert boxing and mixed-martial arts analyst and has provided winning selections to SportsLine members. After a 2021 campaign in which he was able to make numerous boxing matches, he is now coming off a remarkable 2021 campaign.

He predicted that a stoppage victory would be possible between rounds No. Caleb Plant vs Canelo alvarez in their super middleweight unification fight. Proposition selection was paid +450. Wise correctly called the fight to be over 9.5 rounds (-125) and Plant was stopped in Round 11. He also called Jamel Herring (+105), to beat Carl Frampton (125) for the junior lightweight belt. Everyone who has been following Wise's picks for combat sports has seen big returns.

With Saturday's rematch near, Wise has examined Charlo vs. Castano 2, from all angles, and determined the best boxing odds. SportsLine is the only place to see his confident prop wagers and money-line picks.

Castano hosted an open training session earlier in the week for media. He appeared calm and confident when answering questions. Castano stated that he worked with his camp to bring the same level of aggression, but with a better defense that limits Charlo’s ability to counter it.

Castano stated that the fight with Charlo was a learning experience. "One of my biggest lessons was to be more careful when I'm in ring. Although he's strong, I will bring my own power. We have learned from our first fight, and we will correct any mistakes we made.

Castano stated that, while he was not surprised that Charlo and Castano saw their first fight differently but that he is motivated in part by Charlo's insistance at new conferences leading to the rematch in which he beat Charlo by four rounds.

Castano stated that "our press conference was intense" and that our exchanges had motivated him a lot. Castano said that he had seen a different fight from me if he could see himself winning eight rounds. I feel like I won, but I don't know what I saw.

Charlo stated to the media this week that Saturday's historic milestone is what motivates him. He would be the first four-belt champion to become the division's unified champion with a win. He believes that a win will confirm his status as one the most outstanding boxers this generation.

Charlo has also a modest but impressive record in rematches. In December 2018, Charlo lost to Tony Harrison in unanimous decision. This loss cost him the WBC title. He regained his belt one year later with a dominating performance in a rematch that earned him an 11th-round stoppage.

Charlo has one other negative on his record: last year's draw with Castano. Charlo stated that he will make the most of another chance.

Charlo stated that Brian Castano is aware of the fact that he has his hands full again. "But it doesn't matter what they say, It's not about Brian Castano. This is Charlo's chance."

Wise prefers the over 10.5 rounds. Wise also revealed a solid money-line pick, and he has a pair prop picks, one of which returns 3-1. SportsLine is the only place you can see his boxing picks.

Charlo vs. Castano 2, who wins? Which prop is a must back? Check out SportsLine to find Brandon Wise’s top bets on Saturday. All from the CBS combat sport specialist.