Chelsea loan Callum Hudson-Odoi makes his starting XI debut for the Werkself in Bayer Leverkusen's first Champions League group game at Bruges.
As in the two previous Bundesliga games, Seoane relies on a three-man or five-man chain in defense for the Belgian champions. In total, the Swiss coach made four changes. In addition to Hudson-Odoi, Piero Hincapié and Mitchell Bakker, who were suspended against Freiburg, and ex-captain Charles Aranguiz joined the team in defensive midfield. They replace Edmond Tapsoba, Exequiel Palacio, Daley Sinkgraven and Kerem Demirbay.