In Bremerhaven, one of the largest automobile transhipment ports in Europe, a body is found at one of the car terminals - the head of the driver department lies dead in the trunk of a car. The Bremen investigative team Liv Moormann (Jasna Fritzi Bauer) and Linda Selb (Luise Wolfram) take up the investigation and are supported by their Bremerhaven colleague Robert Petersen (Patrick Güldenberg). They meet Marie (Luisa Böse), Gheorghe Rusu (Adrian But) and Oleg Rusu (Jonas Halbfas). The three car tuners secretly swipe cars for nightly races, compete at the "donuts" spin when the car skids in circles with smoking tires. One of the vehicles turns out to be particularly explosive.
Warrior daughter Hua Mulan (Liu Yifei) disguises herself as a man to serve in the army for her ailing father when the Rouran invade her realm. As "Hua Jun" she gets a lot of attention during the war. However, when she reveals her true gender, she is cast out. But then their emperor is to be killed.
Bank clerk Guy's (Ryan Reynolds) days in Free City look the same day after day. When he runs into Molotov Girl (Jodie Comer) aka Millie, he learns from her that he is an NPC - a non-player character - in a computer game. He's shocked at first, but then he's enjoying being free to do whatever he wants - until Free City owner Antwan (Taika Waititi) threatens to shut down the game. Now Guy must save his world together with Millie.
Magic zoologist Newt Scamander (Eddie Redmayne) arrives in New York with a mysterious suitcase. By chance, the magical creature Niffler escapes, causing great chaos in the city. Porpetina sets out to find the runaway and its owner in order to win the favor of the US Magical Congress. However, through a fatal mix-up, even more magical creatures find their way into the open.
A former soldier takes his own life in a home for the disabled. Max (Matthew Beard) and Oskar (Juergen Maurer) investigate on site. They suspect that someone drove the mentally ill man to his death. The late Georg Steiner (Cornelius Obonya) was friends with the father of police archivist Lisa Linder (Miriam Hie). Before Steiner's death, she had asked Max to treat him. Apparently he thought he was cursed. Oskar and Max discover a dark secret from Steiner's time in Beijing.
