A special professional assignment leads Toni Hasler (Leo Reisinger) onto the political stage: He is not only supposed to look after the heavily pregnant family minister Sissi Hopf (Christine Eixenberger), but also to refresh her election campaign. However, what the non-conformist "baby whisperer" brings in poses a real stress test on the conservatives' progress rhetoric.

After Richard Voss (Jan-Gregor Kremp) hung up the handcuffs, a new era dawned. However, the "newcomer", Caspar Bergmann (Thomas Heinze), does not have much time to settle in. He takes over the management of the Munich Homicide Commission with immediate effect. And there is the first case: the bank clerk and family man Martin Feldkamp (Christian Heiner Wolf) was found shot dead on the lake shore.

Broomhilda (Kerry Washington), the wife of slave Django (Jamie Foxx), was kidnapped by the Brittle brothers. One day, Django is captured by bounty hunter Dr. Schultz (Christoph Waltz) taken under his wing. He promises him freedom if he helps him find the gang - dead or alive. Django agrees, not realizing that they have a long road of lead and blood ahead of them.

Police officer John Cale (Channing Tatum) applies to the Secret Service for a job as a bodyguard for the President (Jamie Foxx) and is turned down. When a short time later a paramilitary unit raids the White House and seizes control, the life of the President is suddenly in his hands and Cale finally gets the opportunity to show what he's really made of.

After a routine operation, Julius Mommsen (Leon Blaschke), the 23-year-old paramedic in training, disappears - and with him the ambulance. Radek (Hans-Werner Meyer) and his team learn about the problems of the paramedics from Julius' colleagues Elsa Kubischek (Diane Willems) and Brigitte Zöllner (Susanne Szell): They are increasingly reaching their limits during their operations and therefore develop their own strategies, to deal with the pressure.