The Virological and virologists of the Ruhr showed-Universität Bochum together with colleagues from Jena, Ulm, Duisburg-Essen, Nürnberg and Bremen in cell culture experiments. In the oropharynx of Covid-19-patients can be detected high viral loads. The application of Sars-Cov-2-effective mouthwashes may help, temporarily, the viral load and thus reduce potentially the risk of Transmission of corona virus. This could be, for example, prior dental treatments useful.
mouth rinses are not suitable, however, to treat a Covid-19 infection or to protect themselves from infection with the Virus.
the results of The study describes the Team of Toni masters, Prof. Dr. Stephanie Pfänder and Prof. Dr. Eike Steinmann from Bochum, research group Molecular and Medical Virology the Journal of Infectious Diseases, published online on 29. July 2020. A Review of the laboratory results in clinical studies is still pending.
Eight mouth rinses in the cell culture test
tested substances, The researchers eight mouth rinses with different ingredients that are available in pharmacies or drug stores available in Germany. They mixed each of the mouth rinse with virus particles, and a loading substance, which should reproduce the effect of saliva in the mouth. The mixture was then shaken for 30 seconds, to simulate the effect of the Gurgelns. They then used for the determination of the virus titer of the Vero E6 cells, which are particularly susceptible to Sars-Cov-2. For the evaluation of the effectiveness, the researchers treated researchers used virus suspensions before addition to the cell culture in parallel with cell culture medium instead of mouthwash.
All the tested drugs reduced the initial virus titer. Three mouth rinses reduced it so far that to detect a 30 seconds exposure, no Virus was. If this effect is confirmed in clinical practice, and how long it lasts, must be investigated in further studies.
Clinical studies in work
The Bochum group is examining the possibility of a clinical study on the efficacy of mouth rinses on Sars-Cov-2-viruses, the scientists want to test whether the effect is also detected in patients and how long it lasts. Similar Work is ongoing in San Francisco; the Bochum-based Team is with the US-American researchers in contact.
The Work was funded by the European Union in the framework of the Horizon 2020 programme (grant number 101003555), as well as by the Stiftung Universitätsmedizin Essen.
Toni Louise champion, Yannick Brüggemann, Daniel Todt, Carina Conzelmann, Janis A. Müller, Rüdiger Groß, Jan Münch, Adalbert Krawczyk, Jörg Steinmann, Jochen Steinmann, Stephanie Pfaender, Eike Steinmann: Virucidal efficacy of 1 of the different oral rinses against SARS-CoV-2, in: the Journal of Infectious Diseases, 2020, DOI: 10.1093/infdis/jiaa471
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